Artikels
Aubert, A.E., Beckers, F., Verheyden, B. (2005). Cardiovascular function and basics of physiology in microgravity. Acta Cardiologica 60(2), p. 129-151.
Aviles, H., Belay, T., Fountain, K., Vance, M., Sonnenfeld, G. (2003). Increased susceptibility to Pseudomonas aeroginosa infection under hindlimb unloading conditions. Journal of Applied Physiology 95(1), p. 73-80.
Badwhar, G.D. (1997). The radiation environment in low-Earth orbit. Radiation Research 148(5), p. 313-338.
Baqai, F.P., Gridley, D.S., Slater, J.M., Luo-Owen, X., Stodieck, L.S., Ferguson, V., Chapes, S.K., Pecaut, M.J. (2009). Journal of Applied Physiology 106(6), p. 1935-1942.
Bascove, M., Huin-Schohn, C., Guéguinou, N., Tschirhart, E., Frippiat, J.P. (2009). Spaceflight- associated changes in immunoglobulin VH gene expression in the amphibian Pleurodeles waltl. Journal of the Federation of American Societies for Experimental Biology 23(5), p. 1607-1615.
Bascove, M., Guéguinou, N., Schaerlinger, B., Gauquelin-Koch, G., Frippiat, J.P. (2011). Decrease in antibody somatic hypermutation frequency under extreme, extended spaceflight conditions. Journal of the Federation of American Societies for Experimental Biology 25(9), p. 2947-2955.
Beck, M., Tabury, K., Moreels, M., Jacquet, P., Van Oostveldt, P., De Vos, W.H., Baatout, S. (2012). Simulated microgravity decreases apoptosis in fetal fibroblasts. International Journal of Molecular Medicine 30(2), p. 309-313.
Behnke, B.J., Stabley, J.N., McCullough, D.J., Davis, R.T., Dominguez, J.M., Muller-Delp, J.M., Delp, M.D. (2012). Effects of spaceflight and ground recovery on mesenteric artery and vein constrictor properties in mice. Journal of the Federation of American Societies for Experimental Biology 27(1), p. 399-409.
Berger, A. (2000). Th1 and Th2 responses: what are they? British Medical Journal 321(7258), p. 424.
Black, C.A. (1999). Delayed type hypersensitivity: current theories with an historic perspective. Dermatology Online Journal 5, p. 7.
Boxio, R., Dournon, C., Frippiat, J.P. (2005). Effects of a long-term spaceflight on immunoglobulin heavy chains of the urodele amphibian Pleurodeles waltl. Journal of Applied Physiology 98(3), p. 905-910.
Brinley, A.A., Theriot, C.A., Nelman-Gonzalez, M., Crucian, B., Stowe, R.P., Barrett, A.D., Pierson, D.L. (2012). Characterization of Epstein-Barr virus reactivation in a modeled spaceflight system. Journal of Cellular Biochemistry 114(3), p. 616-624.
Bucker, H., Facius, R., Horneck, G., Reitz, G., Graul, E.H., Berger, H., Hoffken, H., Ruther, W., Heinrich, W., Beaujean, R., Enge, W. (1986). Embryogenesis and organogenesis of Carausius morosus under spaceflight conditions. Advances in Space Research 6(12), p.115-124.
Canova, S., Fiorasi, F., Mognato, M., Grifalconi, M., Reddi, E., Russo, A., Celotti, L. (2005). Modeled microgravity affects cell response to ionizing radiation and increases genomic damage. Radiation Research 163(2), p. 191-199.
Chang, T.T., Walther, I., Li, C.F., Boonyaratanakornkit, J., Galleri, G., Meloni, M.A., Pippia, P., Cogoli, A., Hughes-Fulford, M. (2012). The Rel/NF-κB pathway and transcription of immediate early genes in T cell activation are inhibited by microgravity. Journal of Leukocyte Biology 92(6), p. 1133-1145.
Chereshnev, V.A., Shilov, J.I., Gavrilova, T.V., Usov, V.V., Chereshneva, M.V. (2012). Proliferative response of lymphocyte to pokeweed mitogen depends on the concentration of endogenous cortisol in the early post-traumatic period in patients with penetrating eye injury. Bulletin of Experimental Biology and Medicine 153, p. 722-725.
Choukèr, A., Kaufmann, I., Kreth, S., Hauer, D., Feuerecker, M., Thieme, D., Vogeser, M., Thiel, M., Schelling, G. (2010). Motion Sickness, Stress and the Endocannabinoid System. PLoS One 5(5), e10752.
Cogoli, A., Tschopp, A., Fuchs-Bislin, P. (1984). Cell sensitivity to gravity. Science 225, p. 228- 230.
Cogoli, A. (1996). Gravitational physiology of human immune cells: a review of in vivo, ex vivo and in vitro studies. Journal of Gravitational Physiology 3, p. 1-9.
Cohrs, R.J., Mehta, S.K., Schmid, D.S., Gilden, D.H., Pierson, D.L. (2008). Asymptomatic reactivation and shed of infectious varicella zoster virus in astronauts. Journal of Medical Virology 80, p. 1116-1122.
Cooper, D., Prode, M.W., Brown, E.L., Risin, D., Pellis, N.R. (2001). Suppression of antigen- specific lymphocyte in modeled microgravity. In Vitro Cellular & Developmental Biology 37, p. 63-65.
Crucian, B.E., Stowe, R.P., Pierson, D.L., Sams, C.F. (2008). Immune system dysregulation following short- vs long-duration spaceflight. Aviation, Space, and Environmental Medicine 79(9), p. 835-843.
Crucian, B.E., Stowe, R.P., Mehta, S.K., Yetman, D.L., Leal, M.J., Quiriarte, H.D., Pierson, D.L., Sams, C.F. (2009a). Immune status, latent, viral reactivation, and stress during long-duration head-down bed rest. Aviation, Space, and Environmental Medicine 80, A37-A44.
Crucian, B., Stowe, R., Mehta, S., Uchakin, P., Quiriarte, H., Pierson, D., Sams, C. (2013). Immune system dysregulation occurs during short duration spaceflight on board the Space Shuttle. Journal of Clinical Immunology 33(2), p. 456-465.
Cucinotta, F.A., Kim, M.H., Willingham, V., George, K.A. (2008). Physical and Biological Organ Dosimetry Analysis for International Space Station Astronauts. Radiaton Research 170, p. 127-138.
Dannenberg, A.M. (1991). Delayed-type hypersensitivity and cell- mediated immunity in the pathogenesis of tuberculosis. Immunology Today 12, p. 228-233.
Ferrieu, C., Ballester, B., Mathieu, J., Drouet, E. (2003). Flow cytometry analysis of gamma- radiation-induced Epstein-Barr virus reactivation in lymphocytes. Radiation Research 159, 268-273.
Feuerecker, M., Mayer, W., Kaufmann, I., Gruber, M., Muckenthaler, F., Yi, B., Salam, A.P., Briegel, J., Schelling, G., Thiel, M., Choukèr, A. (2013a). A corticoid-sensitive cytokine release assay for monitoring stress-mediated immune modulation. Clinical & Experimental Immunology 172(2), p. 290-299.
Feuerecker, M., Feuerecker, B., Matzel, S., Long, M., Strewe, C., Kaufmann, I., Hoerl, M., Schelling, G., Rehm, M., Choukèr, A. (2013b). Five days head down tilt bed rest induces non- inflammatory shedding of L-selectin. Journal of Applied Physiology, jap.00381.2013 (published electronically ahead of print).
Fitzgerald, W., Chen, S., Walz, C., Zimmerberg, J., Margolis, L., Grivel, J. (2009). Immune suppression of human lymphoid tissues and cells in rotating suspension culture and onboard the International Space Station. In Vitro Cellular & Developmental Biology 45, p. 622-632.
Gibbs, J.H., Ferguson, J., Brown, R.A., Kenicer, K.J., Potts, R.C., Coghill, G., Swanson Beck, J. (1984). Histometric study of the localisation of lymphocyte subsets and accessory cells in human Mantoux reactions. Journal of Clinical Pathology 37(11), p. 1227-1234.
Girardi, C., De Pittà, C., Casara, S., Sales, G., Lanfranchi, G., Celotti, L., Mognato, M. (2012). Analysis of miRNA and mRNA expression profiles highlights alterations in ionizing radiation response of human lymphocytes under modeled microgravity. PLoS One 7(2), e31293.
Gmünder, F.K., Konstantinova, I., Cogoli, A., Lesnyak, A., Bogomolov, W., Grachov, A.W. (1994). Cellular immunity in cosmonauts during long duration spaceflight on board the orbital MIR station. Aviation, Space and Environmental Medicine 65(5), p. 419-423.
Goossens, O., Vanhavere, F., Leys, N., De Boever, P., O'Sullivan, D., Zhou, D., Spurny, F., Yukihara, E.G., Gaza, R., McKeever, S.W. (2006). Radiation Dosimetry for Microbial Experiments in the International Space Station Using Different Etched Track and Luminescent Detectors. Radiation Protection Dosimetry 120(1-4), p. 433-437.
Gridley, D.S., Slater, J.M., Luo-Owen, X., Rizvi, A., Chapes, S.K., Stodieck, L.S., Ferguson, V.L., Pecaut, M.J. (2009). Spaceflight effects on T lymphocyte distribution, function and gene expression. Journal of Applied Physiology 106, p. 194-202.
Grimm, D., Wise, P., Lebert, M., Richter, P., Baatout, S. (2011). How and why does the proteome respond to microgravity? Expert Review of Proteomics 8(3), p. 13-27.
Grosse, J., Wehland, M., Pietsch, J., Schulz, H., Saar, K., Hübner, N., Eilles, C., Bauer, J., Abou- El-Ardat, K., Baatout, S., Ma, X., Infanger, M., Hemmersbach, R., Grimm, D. (2012). Gravity- sensitive signaling drives 3-dimensional formation of multicellular thyroid cancer spheroids. Journal of the Federation of American Societies for Experimental Biology 26(12), p. 5124- 5140.
Grimm, D., Infanger, M., Westphal, K., Ulbrich, C., Pietsch, J., Kossmehl, P., Vadrucci, S., Baatout, S., Flick, B., Paul, M., Bauer, J. (2009). A delayed type of three-dimensional growth of human endothelial cells under simulated weightlessness. Tissue Engineering Part A. 15(8), p. 2267-2275.
Hashemi, B.B., Penkala, J.E., Vens, C., Huls, H., Cubbage, M., Sams, C.F. (1999). T cell activation responses are differentially regulated during clinorotation and in spaceflight. Journal of the Federation of American Societies for Experimental Biology 13, p. 2071-2082.
Hellweg, C.E., Baumstark-Khan, C. (2007). Getting ready for the manned mission to Mars: the astronauts' risk from space radiation. Naturwissenschaften 94(7), p. 517-526.
Horneck, G. (1992). Radiobiological experiments in space: a review. Nuclear Tracks and Radiation Measurements 20, p. 185-205.
Horneck, G., Rettberg, P., Baumstark-Khan, C., Rink, H., Kozubek, S., Schäfer, M., Schmitz, C. (1996). DNA repair in microgravity: studies on bacteria and mammalian cells in the experiments REPAIR and KINETICS. Biotechnology 47(2-3), p. 99-112.
Horneck, G., Rettberg, P., Kozubek, S., Baumstark-Khan, C., Rink, H., Schäfer, M., Schmitz, C. (1997). The influence of microgravity on repair of radiation-induced DNA damage in bacteria and human fibroblasts. Radiation Research 147(3), p. 376-384.
Horneck, G. (1999). Impact of microgravity on radiobiological processes and efficiency of DNA repair. Mutation Research 430, p. 221-228.
Hoyer, K.K., Dooms, H., Barron, L., Abbas, A.K. (2008). Interleukin-2 in the development and control of inflammatory disease. Immunological Reviews 226, p. 19-28.
Infanger, M., Kossmehl, P. Shakibaei, M., Baatout, S., Witzing, A., Grosse, J., Bauer, J., Cogoli, A., Faramarzi, S., Derradji, H., Neefs, M., Paul, M., Grimm, D. (2006). Induction of three- dimensional assembly and increase in apoptosis of human endothelial cells by simulated microgravity: impact of vascular endothelial growth factor. Apoptosis 11(5), p. 749-764.
Katial, R.K., Sachanandani, D., Pinney, C., Lieberman, M.M. (1998). Cytokine Production in Cell Culture by Peripheral Blood Mononuclear Cells from Immunocompetent Hosts. Clinical and Diagnostic Laboratory Immunology 5(1), p. 78-81.
Kaufmann, I., Schachtner, T., Feuerecker, M., Schelling, G., Thiel, M., Choukèr, A. (2009). Parabolic flight primes cytotoxic capabilities of polymorphonuclear leucocytes in humans. European Journal of Clinical Investigation 39(8), p. 723-728.
Kelsen, J., Bartels, L.E., Dige, A., Hvas, C.L., Frings-Meuthen, P., Boehme, G., Thomsen, M.K., Fenger-Grøn, M., Dahlerup, J.F. (2012). 21 days head-down bed rest induces weakening of cell-mediated immunity: some spaceflight findings confirmed in a ground-based analog. Cytokine 59(2), p. 403-409.
Kiefer, J., Pross, H.D. (1999). Space radiation effects and microgravity. Mutation Research 430, p. 299-305.
Kleiman, N.J. (2013). Radiation cataract. Annals of the International Commission on Radiological Protection 41(3-4), p. 80-97.
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Lebsack, T.W., Fa, V., Woods, C.C., Gruener, R., Manziello, A.M., Pecaut, M.J., Gridley, D.S., Stodieck, L.S., Ferguson, V.L., Deluca, D.J. (2010). Journal of Cellular Biochemistry 110(2), p. 372-814.
Lewis, M.L., Cubano, L.A., Zhao, B., Dinh, H.K., Pabalan, J.G., Piepmeier, E.H., Bowman, P.D. (2001). cDNA microarray reveals altered cytoskeletal gene expression in space-flown leukemic T lymphocytes (Jurkat). Journal of the Federation of American Societies for Experimental Biology 15, p. 1783-1785.
Manti, L., Durante, M., Cirrone, G. A. P., Grossi, G., Lattuada, M., Pugliese, M., Sabini, M. G., Scampoli, P., Valastro, L., Gialanella, G. (2005). Modelled microgravity does not modify the yield of chromosome aberrations induced by high-energy protons in human lymphocytes. International Journal of Radiation Biology 81, p. 147-155.
Manti, L. (2006). Does reduced gravity alter cellular response to ionizing radiation? Radiation and Environmental Biophysics 45, p. 1-8.
Marcu, O., Lera, M.P., Sanchez, M.E., Levic, E., Higgins, L.A., Shmygelska, A., Fahlen, T.F., Nichol, H., Bhattacharya, S. (2011). Innate immune responses of Drosophila melanogaster are altered by spaceflight. PLoS One 6(1), e15361.
McKarns, S.C., Schwartz, R.H. (2008). Biphasic regulation of Il2 transcription in CD4+ T cells: roles for TNF-alpha receptor signaling and chromatin structure. Journal of Immunology 181, p. 1272-1281.
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Mehta, S.K., Cohrs, R.J., Forghani, B., Zerbe, G., Gilden, D.H., Pierson, D.L. (2004). Stress- induced subclinical reactivation of varicella zoster virus in astronauts. Journal of Medical Virology 72, p. 174-179.
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Mognato, M., Girardi, C., Fabris, S., Celotti, L. (2009). DNA repair in modeled microgravity: double strand break rejoining activity in human lymphocytes irradiated with γ-rays. Mutation Research 663(1-2), p. 32-39.
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Nickerson, C.A., Ott, C.M., Wilson, J.W., Ramamurthly, R., LeBlanc, C.L., Höner zu Bentrup, K., Hammond, T., Pierson, D.L. (2003). Low-shear modeled microgravity: a global environmental regulatory signal affecting bacterial gene expression, physiology, and pathogenesis. Journal of Microbiological Methods 54, p. 1-11.
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Boeken
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Moreels, M., de Saint-Georges, L., Vanhavere, F., Baatout, S. (2012a). Stress and Radiation Responsiveness. In “Stress Challenges and Immunity in Space” (Berlin-Heidelberg, Germany, Springer-Verlag), p. 239-260.
Moreels M., Quintens R., Baatout S. (2012b). Assessment of Radiosensitivity and Monitoring of Radiation-Induced Cellular Damage. In “Stress Challenges and Immunity in Space” (Berlin- Heidelberg, Germany, Springer-Verlag), p. 345-356.
Rapporten
Blanc, S. (2013). THESEUS cluster 1 - Integrated Physiology.
Choukèr, A., Morukov, B., Sams, C. (2008). Clinical Immunology in New Frontiers. ESA Spaceflight.
Crucian, B.E., Stowe, R.P., Ott, C.M., Becker, J.L., Haddon, R., McMonigal, K.A., Sams, C.F. (2009b) Human research program: human health countermeasures element. National Aeronautics and Space Administration (NASA).
Cogoli, A., Bechler, A., Mueller, O., Hunzinger, E. (1996). Effects of Microgravity on Lymphocyte Activation. Exp 30011985, STS-61-A, Spacelab D1: Erasmus Experiment Archive.
Handleidingen
Human IL-2 ELISA (Millipore)
Luminex 100TM IS User Manual Version 2.3 (Luminex Coorporation) Luminex xPONENT 3.1 (Revision 2) Software Manual (Luminex Coorporation)
Milliplex Map Kit (Millipore)
Moxi Z mini automated cell counter with new OS 4.0 (ORFLO Technologies)